|Other Names||Keratin, type II cytoskeletal 80, Cytokeratin-80, CK-80, Keratin-80, K80, Type-II keratin Kb20, KRT80, KB20|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Tissue Location||Weakly expressed in tongue, but not skin or in any other tissues or organs examined|
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Keratins are intermediate filament proteins responsiblefor the structural integrity of epithelial cells and are subdividedinto epithelial keratins and hair keratins. This gene's expressionprofile shows that it encodes a type II epithelial keratin,although structurally the encoded protein is more like a type IIhair keratin. This protein is involved in cell differentiation,localizing near desmosomal plaques in earlier stages ofdifferentiation but then dispersing throughout the cytoplasm interminally differentiating cells. The type II keratins areclustered in a region of chromosome 12q13. Two transcript variantsencoding two different fully functional isoforms have been foundfor this gene.
Langbein, L., et al. J. Biol. Chem. 285(47):36909-36921(2010)Lamesch, P., et al. Genomics 89(3):307-315(2007)Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)Rogers, M.A., et al. J. Invest. Dermatol. 124(3):536-544(2005)
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