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KRT80 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6KB66 |
|---|---|
| Clone Names | 100111149 |
| Gene ID | 144501 |
|---|---|
| Other Names | Keratin, type II cytoskeletal 80, Cytokeratin-80, CK-80, Keratin-80, K80, Type-II keratin Kb20, KRT80, KB20 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KRT80 |
|---|---|
| Synonyms | KB20 |
| Tissue Location | Weakly expressed in tongue, but not skin or in any other tissues or organs examined. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Keratins are intermediate filament proteins responsiblefor the structural integrity of epithelial cells and are subdividedinto epithelial keratins and hair keratins. This gene's expressionprofile shows that it encodes a type II epithelial keratin,although structurally the encoded protein is more like a type IIhair keratin. This protein is involved in cell differentiation,localizing near desmosomal plaques in earlier stages ofdifferentiation but then dispersing throughout the cytoplasm interminally differentiating cells. The type II keratins areclustered in a region of chromosome 12q13. Two transcript variantsencoding two different fully functional isoforms have been foundfor this gene.
References
Langbein, L., et al. J. Biol. Chem. 285(47):36909-36921(2010)Lamesch, P., et al. Genomics 89(3):307-315(2007)Schweizer, J., et al. J. Cell Biol. 174(2):169-174(2006)Rogers, M.A., et al. J. Invest. Dermatol. 124(3):536-544(2005)
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