|Other Names||Potassium voltage-gated channel subfamily H member 4, Brain-specific eag-like channel 2, BEC2, Ether-a-go-go-like potassium channel 1, ELK channel 1, ELK1, Voltage-gated potassium channel subunit Kv123, KCNH4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated potassium (Kv) channels represent the mostcomplex class of voltage-gated ion channels from both functionaland structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smoothmuscle contraction, and cell volume. This gene encodes a member ofthe potassium channel, voltage-gated, subfamily H. This member is apore-forming (alpha) subunit. The gene is brain-specific, andlocated in the neocortex and the striatum. It may be involved incellular excitability of restricted neurons in the central nervoussystem.
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)Zou, A., et al. Am. J. Physiol., Cell Physiol. 285 (6), C1356-C1366 (2003) :Miyake, A., et al. J. Biol. Chem. 274(35):25018-25025(1999)
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