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KCNH4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UQ05 |
|---|---|
| Clone Names | 100120037 |
| Gene ID | 23415 |
|---|---|
| Other Names | Potassium voltage-gated channel subfamily H member 4, Brain-specific eag-like channel 2, BEC2, Ether-a-go-go-like potassium channel 1, ELK channel 1, ELK1, Voltage-gated potassium channel subunit Kv123, KCNH4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KCNH4 |
|---|---|
| Function | Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits an outward current, but shows no inactivation. Channel properties may be modulated by cAMP and subunit assembly. |
| Cellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Location | Detected only in brain, in particular in the telencephalon. Detected in putamen and caudate nucleus, and at lower levels in cerebral cortex, occipital and hippocampus |
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Provided below are standard protocols that you may find useful for product applications.
Background
Voltage-gated potassium (Kv) channels represent the mostcomplex class of voltage-gated ion channels from both functionaland structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smoothmuscle contraction, and cell volume. This gene encodes a member ofthe potassium channel, voltage-gated, subfamily H. This member is apore-forming (alpha) subunit. The gene is brain-specific, andlocated in the neocortex and the striatum. It may be involved incellular excitability of restricted neurons in the central nervoussystem.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Gutman, G.A., et al. Pharmacol. Rev. 57(4):473-508(2005)Zou, A., et al. Am. J. Physiol., Cell Physiol. 285 (6), C1356-C1366 (2003) :Miyake, A., et al. J. Biol. Chem. 274(35):25018-25025(1999)
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