|Other Names||Late cornified envelope protein 1A, Late envelope protein 1, LCE1A, LEP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Precursors of the cornified envelope of the stratum corneum.|
|Tissue Location||Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta.|
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Provided below are standard protocols that you may find useful for product applications.
LCE1A belongs to the late cornified envelope (LCE) genecluster within the epidermal differentiation complex (EDC) onchromosome 1. The LCE cluster contains multiple conserved genesthat encode stratum corneum proteins, and these genes are expressedrelatively late during fetal assembly of the skin cornifiedenvelope (Jackson et al., 2005 [PubMed 15854049]). For furtherinformation on the LCE gene cluster, see GENE FAMILYbelow.
Jackson, B., et al. J. Invest. Dermatol. 124(5):1062-1070(2005)Marshall, D., et al. Proc. Natl. Acad. Sci. U.S.A. 98(23):13031-13036(2001)
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