|Other Names||Vacuolar protein sorting-associated protein 52 homolog, SAC2 suppressor of actin mutations 2-like protein, VPS52, SACM2L|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (PubMed:15878329, PubMed:18367545). Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane (PubMed:25799061).|
|Cellular Location||Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein Endosome membrane; Peripheral membrane protein. Recycling endosome. Note=Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex (PubMed:25799061)|
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This gene encodes a protein that is similar to the yeastsuppressor of actin mutations 2 gene. The yeast protein forms asubunit of the tetrameric Golgi-associated retrograde proteincomplex that is involved in vesicle trafficking from from bothearly and late endosomes, back to the trans-Golgi network. Thisgene is located on chromosome 6 in a head-to-head orientation withthe gene encoding ribosomal protein S18.
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009) :Perez-Victoria, F.J., et al. Mol. Cell. Biol. 29(19):5251-5263(2009)Perez-Victoria, F.J., et al. Mol. Biol. Cell 19(6):2350-2362(2008)Liewen, H., et al. Exp. Cell Res. 306(1):24-34(2005)Mungall, A.J., et al. Nature 425(6960):805-811(2003)
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