|Other Names||C-terminal-binding protein 1, CtBP1, 111-, CTBP1, CTBP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expressed in germinal center B-cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that binds to the C-terminusof adenovirus E1A proteins. This phosphoprotein is atranscriptional repressor and may play a role during cellularproliferation. This protein and the product of a second closelyrelated gene, CTBP2, can dimerize. Both proteins can also interactwith a polycomb group protein complex which participates inregulation of gene expression during development. Alternativesplicing of transcripts from this gene results in multipletranscript variants.
Roukens, M.G., et al. Nat. Cell Biol. 12(10):933-942(2010)Choi, H.J., et al. Biochem. Biophys. Res. Commun. 400(3):396-402(2010)Merrill, J.C., et al. J. Mol. Biol. 398(5):657-671(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Yoshida, T., et al. Int. J. Mol. Med. 25(4):649-656(2010)
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