|Other Names||39S ribosomal protein L51, mitochondrial, L51mt, MRP-L51, bMRP-64, bMRP64, MRPL51, MRP64|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion EMBL; AB049959; BAB41012.1; -; mRNA EMBL; AF212248; AAK14931.1; -; mRNA EMBL; AF151075; AAF36161.1; -; mRNA EMBL; BC000191; AAH00191.1; -; mRNA EMBL; BC014329; AAH14329.1; -; mRNA EMBL; AB051355; BAB54944.1; -; Genomic_DNA CCDS; CCDS8547.1; - RefSeq; NP_057581.2; NM_016497.3 UniGene; Hs.55847; - PDB; 3J7Y; EM; 3.40 A; i=1-128 PDB; 3J9M; EM; 3.50 A; i=1-128 PDBsum; 3J7Y; - PDBsum; 3J9M; - ProteinModelPortal; Q4U2R6; - SMR; Q4U2R6; - BioGrid; 119414; 31 IntAct; Q4U2R6; 4 MINT; MINT-6775055; - STRING; 9606.ENSP00000229238; - BioMuta; MRPL51; - DMDM; 74762954; - EPD; Q4U2R6; - MaxQB; Q4U2R6; - PaxDb; Q4U2R6; - PeptideAtlas; Q4U2R6; - PRIDE; Q4U2R6; - TopDownProteomics; Q4U2R6; - Ensembl; ENST00000229238; ENSP00000229238; ENSG00000111639 GeneID; 51258; - KEGG; hsa:51258; - UCSC; uc001qom.3; human CTD; 51258; - GeneCards; MRPL51; - HGNC; HGNC:14044; MRPL51 HPA; HPA039923; - MIM; 611855; gene neXtProt; NX_Q4U2R6; - OpenTargets; ENSG00000111639; - PharmGKB; PA30984; - eggNOG; KOG4045; Eukaryota eggNOG; ENOG4111M24; LUCA GeneTree; ENSGT00390000018821; - HOGENOM; HOG000154145; - HOVERGEN; HBG093901; - InParanoid; Q4U2R6; - KO; K17432; - OMA; FNRHGKY; - OrthoDB; EOG091G0V79; - PhylomeDB; Q4U2R6; - TreeFam; TF106130; - Reactome; R-HSA-5368286; Mitochondrial translation initiation Reactome; R-HSA-5389840; Mitochondrial translation elongation Reactome; R-HSA-5419276; Mitochondrial translation termination ChiTaRS; MRPL51; human GenomeRNAi; 51258; - PRO; PR:Q4U2R6; - Proteomes; UP000005640; Chromosome 12 Bgee; ENSG00000111639; - CleanEx; HS_MRPL51; - ExpressionAtlas; Q4U2R6; baseline and differential Genevisible; Q4U2R6; HS GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB GO; GO:0005761; C:mitochondrial ribosome; IDA:UniProtKB GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB GO; GO:0070125; P:mitochondrial translational elongation; TAS:Reactome GO; GO:0070126; P:mitochondrial translational termination; TAS:Reactome GO; GO:0006412; P:translation; ISS:UniProtKB InterPro; IPR019373; Ribosomal_L51_mit Pfam; PF10244; MRP-L51; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide TRANSIT 1 31 Mitochondrion. CHAIN 32 128 39S ribosomal protein L51, mitochondrial /FTId=PRO_0000273082 VARIANT 102 102 M -> I (in dbSNP:rs9526) /FTId=VAR_030079 CONFLICT 79 79 W -> R (in Ref. 3; AAF36161) SEQUENCE 128 AA; 15095 MW; 9DB4720D5B387A5D CRC64; MAGNLLSGAG RRLWDWVPLA CRSFSLGVPR LIGIRLTLPP PKVVDRWNEK RAMFGVYDNI GILGNFEKHP KELIRGPIWL RGWKGNELQR CIRKRKMVGS RMFADDLHNL NKRIRYLYKH FNRHGKFR|
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Provided below are standard protocols that you may find useful for product applications.
Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of asmall 28S subunit and a large 39S subunit. They have an estimated75% protein to rRNA composition compared to prokaryotic ribosomes,where this ratio is reversed. Another difference between mammalianmitoribosomes and prokaryotic ribosomes is that the latter containa 5S rRNA. Among different species, the proteins comprising themitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequencehomology. This gene encodes a 39S subunit protein. Pseudogenescorresponding to this gene are found on chromosomes 4p and 21q.
Zhang, Z., et al. Genomics 81(5):468-480(2003)Koc, E.C., et al. J. Biol. Chem. 276(47):43958-43969(2001)Kenmochi, N., et al. Genomics 77 (1-2), 65-70 (2001) :Suzuki, T., et al. J. Biol. Chem. 276(35):33181-33195(2001)
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