|Other Names||Mediator of RNA polymerase II transcription subunit 4, Activator-recruited cofactor 36 kDa component, ARC36, Mediator complex subunit 4, TRAP/SMCC/PC2 subunit p36 subunit, Vitamin D3 receptor-interacting protein complex 36 kDa component, DRIP36, MED4, ARC36, DRIP36, VDRIP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||ARC36, DRIP36, VDRIP|
|Function||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|
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The Mediator is a multiprotein coactivator that isrequired by DNA-binding transcription factors for activation ofpolymerase II (see MIM 180660)-transcribed genes. MED4 appears tobe a core Mediator subunit and is found in nearly all Mediatorpreparations (summary by Sato et al., 2004 [PubMed15175163]).
Panierakis, C., et al. Int. J. Infect. Dis. 13 (6), E437-E443 (2009) :Kob, R., et al. Cell Cycle 6(8):993-996(2007)Conaway, J.W., et al. FEBS Lett. 579(4):904-908(2005)Colland, F., et al. Genome Res. 14(7):1324-1332(2004)Sato, S., et al. Mol. Cell 14(5):685-691(2004)
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