CASP5 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P51878 |
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Clone Names | 80410105 |
Gene ID | 838 |
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Other Names | Caspase-5, CASP-5, ICE(rel)-III, Protease ICH-3, Protease TY, Caspase-5 subunit p20, Caspase-5 subunit p10, CASP5, ICH3 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CASP5 {ECO:0000303|PubMed:16893518, ECO:0000312|HGNC:HGNC:1506} |
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Function | Thiol protease that acts as a mediator of programmed cell death (PubMed:29898893, PubMed:28314590). Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin- D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (PubMed:29898893). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). |
Tissue Location | Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the cysteine-aspartic acidprotease (caspase) family. Sequential activation of caspases playsa central role in the execution-phase of cell apoptosis. Caspasesexist as inactive proenzymes which undergo proteolytic processingat conserved aspartic residues to produce two subunits, large andsmall, that dimerize to form the active enzyme. Overexpression ofthe active form of this enzyme induces apoptosis in fibroblasts.Max, a central component of the Myc/Max/Mad transcriptionregulation network important for cell growth, differentiation, andapoptosis, is cleaved by this protein; this process requiresFas-mediated dephosphorylation of Max. The expression of this geneis regulated by interferon-gamma and lipopolysaccharide.Alternatively spliced transcript variants have been identified forthis gene.
References
Ulybina, Y.M., et al. Exp. Gerontol. 45(9):726-729(2010)Notaridou, M., et al. Int. J. Cancer (2010) In press :Kim, M.S., et al. APMIS 118(4):308-312(2010)Liang, X.S., et al. Br. J. Haematol. 146(4):418-423(2009)Eckhart, L., et al. Biochem. Biophys. Res. Commun. 348(2):682-688(2006)
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