|Other Names||Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2, CDKN1C, KIP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.|
|Tissue Location||Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.|
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This gene is imprinted, with preferential expression ofthe maternal allele. The encoded protein is a tight-binding, stronginhibitor of several G1 cyclin/Cdk complexes and a negativeregulator of cell proliferation. Mutations in this gene areimplicated in sporadic cancers and Beckwith-Wiedemann syndorome,suggesting that this gene is a tumor suppressor candidate. Threetranscript variants encoding two different isoforms have been foundfor this gene.
O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)Madhavan, J., et al. Ophthalmic Genet. 31(3):141-146(2010)Romanelli, V., et al. Am. J. Med. Genet. A 152A (6), 1390-1397 (2010) :Hoffner, L., et al. J Reprod Med 55 (5-6), 219-228 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
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