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CDKN1C Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P49918
Clone Names 80722029
Peptide ID 80722029
Additional Information
Gene ID 1028
Other Names Cyclin-dependent kinase inhibitor 1C, Cyclin-dependent kinase inhibitor p57, p57Kip2, CDKN1C, KIP2
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIP2
Function Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non- proliferative state throughout life.
Cellular Location Nucleus.
Tissue Location Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. Expressed in the eye. High levels are seen in the placenta while low levels are seen in the liver.
Research Areas
Citations (0)

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This gene is imprinted, with preferential expression ofthe maternal allele. The encoded protein is a tight-binding, stronginhibitor of several G1 cyclin/Cdk complexes and a negativeregulator of cell proliferation. Mutations in this gene areimplicated in sporadic cancers and Beckwith-Wiedemann syndorome,suggesting that this gene is a tumor suppressor candidate. Threetranscript variants encoding two different isoforms have been foundfor this gene.


O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)Madhavan, J., et al. Ophthalmic Genet. 31(3):141-146(2010)Romanelli, V., et al. Am. J. Med. Genet. A 152A (6), 1390-1397 (2010) :Hoffner, L., et al. J Reprod Med 55 (5-6), 219-228 (2010) :Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :

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$ 80.00
Cat# BP10945a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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