|Other Names||Histone-lysine N-methyltransferase SMYD1, SET and MYND domain-containing protein 1, SMYD1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Expression seems mostly restricted to heart and skeletal muscle.|
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Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis (By similarity).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Yang, J., et al. J. Mol. Biol. 386(4):938-950(2009)Sims, R.J. III, et al. J. Biol. Chem. 277(29):26524-26529(2002)Gottlieb, P.D., et al. Nat. Genet. 31(1):25-32(2002)Srivastava, D., et al. Cold Spring Harb. Symp. Quant. Biol. 67, 121-125 (2002) :
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