|Other Names||Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6, CDKN2C, CDKN6|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.|
|Tissue Location||Highest levels found in skeletal muscle. Also found in pancreas and heart|
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The protein encoded by this gene is a member of the INK4family of cyclin-dependent kinase inhibitors. This protein has beenshown to interact with CDK4 or CDK6, and prevent the activation ofthe CDK kinases, thus function as a cell growth regulator thatcontrols cell cycle G1 progression. Ectopic expression of this genewas shown to suppress the growth of human cells in a manner thatappears to correlate with the presence of a wild-type RB1 function.Studies in the knockout mice suggested the roles of this gene inregulating spermatogenesis, as well as in suppressingtumorigenesis. Two alternatively spliced transcript variants ofthis gene, which encode an identical protein, have been reported.
Stratakis, C., et al. Clin. Genet. 78(5):457-463(2010)Cunningham, J.M., et al. Br. J. Cancer 101(8):1461-1468(2009)Eguchi, T., et al. Mol. Cancer Ther. 8(6):1460-1472(2009)Pei, X.H., et al. Cancer Cell 15(5):389-401(2009)Hossain, M.G., et al. Endocr. Pathol. 20(2):114-121(2009)
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