|Other Names||Catechol O-methyltransferase, COMT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.|
|Cellular Location||Isoform Soluble: Cytoplasm.|
|Tissue Location||Brain, liver, placenta, lymphocytes and erythrocytes|
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Provided below are standard protocols that you may find useful for product applications.
Catechol-O-methyltransferase catalyzes the transfer of amethyl group from S-adenosylmethionine to catecholamines, includingthe neurotransmitters dopamine, epinephrine, and norepinephrine.This O-methylation results in one of the major degradative pathwaysof the catecholamine transmitters. In addition to its role in themetabolism of endogenous substances, COMT is important in themetabolism of catechol drugs used in the treatment of hypertension,asthma, and Parkinson disease. COMT is found in two forms intissues, a soluble form (S-COMT) and a membrane-bound form(MB-COMT). The differences between S-COMT and MB-COMT reside withinthe N-termini. Several transcript variants are formed through theuse of alternative translation initiation sites and promoters.
Paloyelis, Y., et al. Neuropsychopharmacology 35(12):2414-2426(2010)Stroth, S., et al. Neurobiol Learn Mem 94(3):364-372(2010)Lim, J.H., et al. Pharmacogenet. Genomics 20(10):605-610(2010)Demetrovics, Z., et al. Compr Psychiatry 51(5):510-515(2010)Bodenmann, S., et al. Sleep 33(8):1027-1035(2010)
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