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DEFB1 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P60022
Clone Names 90713054
Peptide ID 90713054
Additional Information
Gene ID 1672
Other Names Beta-defensin 1, BD-1, hBD-1, Defensin, beta 1, DEFB1, BD1, HBD1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DEFB1
Synonyms BD1, HBD1
Function Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).
Cellular Location Secreted.
Tissue Location Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).
Research Areas
Citations (0)

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Background

Defensins form a family of microbicidal and cytotoxicpeptides made by neutrophils. Members of the defensin family arehighly similar in protein sequence. This gene encodes defensin,beta 1, an antimicrobial peptide implicated in the resistance ofepithelial surfaces to microbial colonization. This gene maps inclose proximity to defensin family member, defensin, alpha 1 andhas been implicated in the pathogenesis of cystic fibrosis.

References

Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Garreis, F., et al. Histochem. Cell Biol. 134(1):59-73(2010)Segat, L., et al. Int. J. Dermatol. 49(6):653-657(2010)Tiszlavicz, Z., et al. Pancreatology 10(4):483-490(2010)Yin, L., et al. BMC Immunol. 11, 37 (2010) :

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$ 80.00
Cat# BP10958a
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