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DEFB1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P60022 |
|---|---|
| Clone Names | 90713054 |
| Gene ID | 1672 |
|---|---|
| Other Names | Beta-defensin 1, BD-1, hBD-1, Defensin, beta 1, DEFB1, BD1, HBD1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DEFB1 |
|---|---|
| Synonyms | BD1, HBD1 |
| Function | Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). |
| Cellular Location | Secreted. Membrane. Note=Associates with tumor cell membrane-derived microvesicles (PubMed:23938203) |
| Tissue Location | Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Defensins form a family of microbicidal and cytotoxicpeptides made by neutrophils. Members of the defensin family arehighly similar in protein sequence. This gene encodes defensin,beta 1, an antimicrobial peptide implicated in the resistance ofepithelial surfaces to microbial colonization. This gene maps inclose proximity to defensin family member, defensin, alpha 1 andhas been implicated in the pathogenesis of cystic fibrosis.
References
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Garreis, F., et al. Histochem. Cell Biol. 134(1):59-73(2010)Segat, L., et al. Int. J. Dermatol. 49(6):653-657(2010)Tiszlavicz, Z., et al. Pancreatology 10(4):483-490(2010)Yin, L., et al. BMC Immunol. 11, 37 (2010) :
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