|Other Names||Beta-defensin 1, BD-1, hBD-1, Defensin, beta 1, DEFB1, BD1, HBD1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636).|
|Tissue Location||Blood plasma. Sperm. Highly expressed in the lower head and midpiece of sperm. Significantly reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level).|
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Defensins form a family of microbicidal and cytotoxicpeptides made by neutrophils. Members of the defensin family arehighly similar in protein sequence. This gene encodes defensin,beta 1, an antimicrobial peptide implicated in the resistance ofepithelial surfaces to microbial colonization. This gene maps inclose proximity to defensin family member, defensin, alpha 1 andhas been implicated in the pathogenesis of cystic fibrosis.
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Garreis, F., et al. Histochem. Cell Biol. 134(1):59-73(2010)Segat, L., et al. Int. J. Dermatol. 49(6):653-657(2010)Tiszlavicz, Z., et al. Pancreatology 10(4):483-490(2010)Yin, L., et al. BMC Immunol. 11, 37 (2010) :
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