|Other Names||Inter-alpha-trypsin inhibitor heavy chain H5, ITI heavy chain H5, ITI-HC5, Inter-alpha-inhibitor heavy chain 5, ITIH5, KIAA1953|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May act as a tumor suppressor.|
|Tissue Location||Abundantly expressed in placenta. Less abundant expression in mammary gland and ovary. Expression is barely detectable levels in all other tissues tested|
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This gene encodes a heavy chain component of one of theinter-alpha-trypsin inhibitor (ITI) family members. ITI proteinsare involved in extracellular matrix stabilization and in theprevention of tumor metastasis. They are also structurally relatedplasma serine protease inhibitors and are composed of a light chainand varying numbers of heavy chains. This family member is thoughtto function as a tumor suppressor in breast and thyroid cancers.Alternative splicing results in multiple transcript variants.
Pita, J.M., et al. Br. J. Cancer 101(10):1782-1791(2009)Veeck, J., et al. Pathologe 29 SUPPL 2, 338-346 (2008) :Veeck, J., et al. Oncogene 27(6):865-876(2008)Hamm, A., et al. BMC Cancer 8, 25 (2008) :Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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