|Other Names||B-cell lymphoma/leukemia 11B, BCL-11B, B-cell CLL/lymphoma 11B, COUP-TF-interacting protein 2, Radiation-induced tumor suppressor gene 1 protein, hRit1, BCL11B, CTIP2, RIT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element (By similarity).|
|Tissue Location||Highly expressed in brain and in malignant T- cell lines derived from patients with adult T-cell leukemia/lymphoma|
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This gene encodes a C2H2-type zinc finger protein and isclosely related to BCL11A, a gene whose translocation may beassociated with B-cell malignancies. The specific function of thisgene has not yet been determined. Two alternatively splicedtranscript variants, which encode distinct isoforms, have beenreported.
Ganguli-Indra, G., et al. Exp. Dermatol. 18(11):994-996(2009)Cherrier, T., et al. Oncogene 28(38):3380-3389(2009)Ganguli-Indra, G., et al. PLoS ONE 4 (4), E5367 (2009) :Cismasiu, V.B., et al. Virology 380(2):173-181(2008)Desplats, P.A., et al. Neurobiol. Dis. 31(3):298-308(2008)
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