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MC4R Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P32245 |
|---|---|
| Clone Names | 90723082 |
| Gene ID | 4160 |
|---|---|
| Other Names | Melanocortin receptor 4, MC4-R, MC4R |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | MC4R |
|---|---|
| Function | Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Brain, placental, and gut tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a membrane-boundreceptor and member of the melanocortin receptor family. Theencoded protein interacts with adrenocorticotropic and MSH hormonesand is mediated by G proteins. This is an intronless gene. Defectsin this gene are a cause of autosomal dominant obesity. [providedby RefSeq].
References
Hotta, K., et al. J. Hum. Genet. 55(11):738-742(2010)Roubert, P., et al. J. Endocrinol. 207(2):177-183(2010)Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Sarzynski, M.A., et al. Int J Obes (Lond) (2010) In press :
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