|Other Names||Melanocortin receptor 4, MC4-R, MC4R|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Brain, placental, and gut tissues.|
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The protein encoded by this gene is a membrane-boundreceptor and member of the melanocortin receptor family. Theencoded protein interacts with adrenocorticotropic and MSH hormonesand is mediated by G proteins. This is an intronless gene. Defectsin this gene are a cause of autosomal dominant obesity. [providedby RefSeq].
Hotta, K., et al. J. Hum. Genet. 55(11):738-742(2010)Roubert, P., et al. J. Endocrinol. 207(2):177-183(2010)Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Sarzynski, M.A., et al. Int J Obes (Lond) (2010) In press :
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