|Other Names||Fos-related antigen 2, FRA-2, FOSL2, FRA2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.|
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Provided below are standard protocols that you may find useful for product applications.
The Fos gene family consists of 4 members: FOS, FOSB,FOSL1, and FOSL2. These genes encode leucine zipper proteins thatcan dimerize with proteins of the JUN family, thereby forming thetranscription factor complex AP-1. As such, the FOS proteins havebeen implicated as regulators of cell proliferation,differentiation, and transformation.
Bozec, A., et al. J. Cell Biol. 190(6):1093-1106(2010)Bolat, I., et al. Folia Histochem. Cytobiol. 48(2):197-201(2010)Reich, N., et al. Arthritis Rheum. 62(1):280-290(2010)Maurer, B., et al. Circulation 120(23):2367-2376(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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