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ANAPC5 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UJX4 |
|---|---|
| Clone Names | 90819114 |
| Gene ID | 51433 |
|---|---|
| Other Names | Anaphase-promoting complex subunit 5, APC5, Cyclosome subunit 5, ANAPC5, APC5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ANAPC5 |
|---|---|
| Synonyms | APC5 |
| Function | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. |
| Cellular Location | Nucleus. Cytoplasm, cytoskeleton, spindle |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a tetratricopeptide repeat-containingcomponent of the anaphase promoting complex/cyclosome (APC/C), alarge E3 ubiquitin ligase that controls cell cycle progression bytargeting a number of cell cycle regulators such as B-type cyclinsfor 26S proteasome-mediated degradation through ubiquitination. Theencoded protein is required for the proper ubiquitination functionof APC/C and for the interaction of APC/C with transcriptioncoactivators. It also interacts with polyA binding protein andrepresses internal ribosome entry site-mediated translation.Multiple transcript variants encoding different isoforms have beenfound for this gene. These differences cause translation initiationat a downstream AUG and result in a shorter protein (isoform b),compared to isoform a.
References
Wasch, R., et al. Oncogene 29(1):1-10(2010)Jin, L., et al. Cell 133(4):653-665(2008)Liu, J., et al. Cancer Biol. Ther. 5(7):760-762(2006)Dube, P., et al. Mol. Cell 20(6):867-879(2005)Turnell, A.S., et al. Nature 438(7068):690-695(2005)
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