|Other Names||Anaphase-promoting complex subunit 5, APC5, Cyclosome subunit 5, ANAPC5, APC5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a tetratricopeptide repeat-containingcomponent of the anaphase promoting complex/cyclosome (APC/C), alarge E3 ubiquitin ligase that controls cell cycle progression bytargeting a number of cell cycle regulators such as B-type cyclinsfor 26S proteasome-mediated degradation through ubiquitination. Theencoded protein is required for the proper ubiquitination functionof APC/C and for the interaction of APC/C with transcriptioncoactivators. It also interacts with polyA binding protein andrepresses internal ribosome entry site-mediated translation.Multiple transcript variants encoding different isoforms have beenfound for this gene. These differences cause translation initiationat a downstream AUG and result in a shorter protein (isoform b),compared to isoform a.
Wasch, R., et al. Oncogene 29(1):1-10(2010)Jin, L., et al. Cell 133(4):653-665(2008)Liu, J., et al. Cancer Biol. Ther. 5(7):760-762(2006)Dube, P., et al. Mol. Cell 20(6):867-879(2005)Turnell, A.S., et al. Nature 438(7068):690-695(2005)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.