|Other Names||Beta-1, 3-galactosyl-O-glycosyl-glycoprotein beta-1, 6-N-acetylglucosaminyltransferase 3, C2GnT-mucin type, C2GnT-M, hC2GnT-M, Core 2/core 4 beta-1, 6-N-acetylglucosaminyltransferase, C2/4GnT, GCNT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development.|
|Cellular Location||Golgi apparatus membrane; Single-pass type II membrane protein|
|Tissue Location||Primarily expressed in mucus-secreting tissues. Expressed in colon, kidney, small intestine, trachea, and stomach, where mucin is produced.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of theN-acetylglucosaminyltransferase family. The encoded protein is abeta-6-N-acetylglucosamine-transferase that catalyzes the formationof core 2 and core 4 O-glycans on mucin-type glycoproteins.
Tan, S., et al. Am. J. Respir. Cell Mol. Biol. 36(6):737-745(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Huang, M.C., et al. Oncogene 25(23):3267-3276(2006)Beum, P.V., et al. Am. J. Respir. Cell Mol. Biol. 29(1):48-56(2003)Schwientek, T., et al. J. Biol. Chem. 274(8):4504-4512(1999)
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