|Other Names||WAS/WASL-interacting protein family member 2, WASP-interacting protein-related protein, WIP- and CR16-homologous protein, WIP-related protein, WIPF2, WICH, WIRE|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system.|
|Cellular Location||Cytoplasm, cytoskeleton Note=Localized to stress fibers and bundles of actin filaments|
|Tissue Location||Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta|
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This gene encodes a WASP interacting protein (WIP)-relatedprotein. It has been shown that this protein has a role in theWASP-mediated organization of the actin cytoskeleton and that thisprotein is a potential link between the activated platelet-derivedgrowth factor receptor and the actin polymerization machinery.
Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Salazar, M.A., et al. J. Biol. Chem. 278(49):49031-49043(2003)Aspenstrom, P. Exp. Cell Res. 279(1):21-33(2002)Kato, M., et al. Biochem. Biophys. Res. Commun. 291(1):41-47(2002)
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