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CE164 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9UPV0
Clone Names 91113176
Peptide ID 91113176
Additional Information
Gene ID 22897
Other Names Centrosomal protein of 164 kDa, Cep164, CEP164, KIAA1052, NPHP15
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CEP164
Synonyms KIAA1052, NPHP15
Function Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1.
Cellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis Expressed in chromatin-enriched nuclear fraction of HeLa cells. In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1
Tissue Location Expressed in several cell lines.
Research Areas
Citations (0)

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Background

Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA,CHK2 and CHK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHK1.

References

Pan, Y.R., et al. Cell Cycle 8(4):655-664(2009)Sivasubramaniam, S., et al. Genes Dev. 22(5):587-600(2008)Graser, S., et al. J. Cell Biol. 179(2):321-330(2007)Petretti, C., et al. EMBO Rep. 7(4):418-424(2006)Zick, A., et al. Nucleic Acids Res. 33(13):4235-4242(2005)

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$ 80.00
Cat# BP10981a
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