|Other Names||B-cell CLL/lymphoma 7 protein family member A, BCL7A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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This gene is directly involved, with Myc and IgH, in athree-way gene translocation in a Burkitt lymphoma cell line. As aresult of the gene translocation, the N-terminal region of the geneproduct is disrupted, which is thought to be related to thepathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma.The N-terminal segment involved in the translocation includes theregion that shares a strong sequence similarity with those of BCL7Band BCL7C. Two transcript variants encoding different isoforms havebeen found for this gene.
Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009)Liang, X.S., et al. Br. J. Haematol. 146(4):418-423(2009)Morton, L.M., et al. Cancer Epidemiol. Biomarkers Prev. 18(4):1259-1270(2009)Carbone, A., et al. Genes Chromosomes Cancer 47(12):1067-1075(2008)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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