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JMJD5 Antibody (N-term) Blocking PeptidesSynthetic peptide
| Country | United States
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| Catalog # | Size | Availability | Price | |
| BP10986a | 0.1 mg 400 ul | In Stock | $ 45.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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- Backgrounds
JMJD5 Antibody (N-term) Blocking Peptides - Product info | |
| Primary Accession | Q8N371 |
| Clone Names | 90826186 |
| Calculated MW | 47270 Da |
JMJD5 Antibody (N-term) Blocking Peptides - Additional info | |
| Gene ID 79831 | |
| Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. | |
| Precautions This product is for research use only. Not for use in diagnostic or therapeutic procedures. | |
JMJD5 Antibody (N-term) Blocking Peptides - Protein Information | |
| Name KDM8 | |
| Synonyms JMJD5 | |
| Function Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation | |
| Cellular Location Nucleus. | |
| Tissue Location Weakly expressed in most cells. Highly expressed in breast cancer cells | |
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BACKGROUND
This gene likely encodes a histone lysine demethylase.Studies of a similar protein in mouse indicate a potential role forthis protein as a tumor suppressor. Alternatively splicedtranscript variants have been described.
REFERENCES
Hsia, D.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9671-9676(2010)Shi, Y. Nat. Rev. Genet. 8(11):829-833(2007)Suzuki, T., et al. EMBO J. 25(14):3422-3431(2006)
