|Other Names||Lysine-specific demethylase 8, JmjC domain-containing protein 5, Jumonji domain-containing protein 5, KDM8, JMJD5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation.|
|Tissue Location||Weakly expressed in most cells. Highly expressed in breast cancer cells.|
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Provided below are standard protocols that you may find useful for product applications.
This gene likely encodes a histone lysine demethylase.Studies of a similar protein in mouse indicate a potential role forthis protein as a tumor suppressor. Alternatively splicedtranscript variants have been described.
Hsia, D.A., et al. Proc. Natl. Acad. Sci. U.S.A. 107(21):9671-9676(2010)Shi, Y. Nat. Rev. Genet. 8(11):829-833(2007)Suzuki, T., et al. EMBO J. 25(14):3422-3431(2006)
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