|Other Names||Bcl-2-associated transcription factor 1, Btf, BCLAF1, BTF, KIAA0164|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.|
|Cellular Location||Cytoplasm. Nucleus. Nucleus speckle. Nucleus, nucleoplasm|
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This gene encodes a transcriptional repressor thatinteracts with several members of the BCL2 family of proteins.Overexpression of this protein induces apoptosis, which can besuppressed by co-expression of BCL2 proteins. The protein localizesto dot-like structures throughout the nucleus, and redistributes toa zone near the nuclear envelope in cells undergoing apoptosis.Multiple transcript variants encoding different isoforms have beenfound for this gene.
Sarras, H., et al. ScientificWorldJournal 10, 1450-1461 (2010) :Renert, A.F., et al. J. Proteome Res. 8(10):4810-4822(2009)Liu, H., et al. Mol. Cell. Biol. 27(24):8480-8491(2007)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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