|Other Names||Protein FAM162A, E2-induced gene 5 protein, Growth and transformation-dependent protein, HGTD-P, FAM162A, C3orf28, E2IG5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.|
|Cellular Location||Membrane; Single-pass membrane protein. Mitochondrion|
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O'Seaghdha, C.M., et al. Hum. Mol. Genet. 19(21):4296-4303(2010)Qu, Y., et al. Stroke 40(8):2843-2848(2009)Cho, Y.E., et al. Hum. Pathol. 40(7):975-981(2009)Kim, J.Y., et al. FEBS Lett. 580(13):3270-3275(2006)Lee, M.J., et al. Mol. Cell. Biol. 24(9):3918-3927(2004)
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