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RT34 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P82930
Clone Names 91113290
Peptide ID 91113290
Additional Information
Other Names 28S ribosomal protein S34, mitochondrial, MRP-S34, S34mt, MRPS34
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name MRPS34
Function Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.
Cellular Location Mitochondrion. EMBL; BC001182; AAH01182.1; -; mRNA CCDS; CCDS10444.1; - RefSeq; NP_001287829.1; NM_001300900.1 RefSeq; NP_076425.1; NM_023936.1 UniGene; Hs.720388; - PDB; 3J9M; EM; 3.50 A; A0=1-218 PDBsum; 3J9M; - ProteinModelPortal; P82930; - BioGrid; 122442; 78 IntAct; P82930; 10 STRING; 9606.ENSP00000380531; - iPTMnet; P82930; - PhosphoSitePlus; P82930; - SwissPalm; P82930; - BioMuta; MRPS34; - DMDM; 24212369; - EPD; P82930; - MaxQB; P82930; - PaxDb; P82930; - PeptideAtlas; P82930; - PRIDE; P82930; - TopDownProteomics; P82930; - DNASU; 65993; - Ensembl; ENST00000397375; ENSP00000380531; ENSG00000074071 GeneID; 65993; - KEGG; hsa:65993; - UCSC; uc002cmo.4; human CTD; 65993; - GeneCards; MRPS34; - HGNC; HGNC:16618; MRPS34 HPA; HPA042112; - MIM; 611994; gene neXtProt; NX_P82930; - OpenTargets; ENSG00000074071; - PharmGKB; PA31021; - eggNOG; ENOG410IGV1; Eukaryota eggNOG; ENOG4111FKH; LUCA GeneTree; ENSGT00390000008964; - HOGENOM; HOG000154216; - HOVERGEN; HBG036130; - InParanoid; P82930; - KO; K17412; - PhylomeDB; P82930; - TreeFam; TF320386; - BioCyc; ZFISH:ENSG00000074071-MONOMER; - Reactome; R-HSA-5368286; Mitochondrial translation initiation Reactome; R-HSA-5389840; Mitochondrial translation elongation Reactome; R-HSA-5419276; Mitochondrial translation termination ChiTaRS; MRPS34; human GenomeRNAi; 65993; - PRO; PR:P82930; - Proteomes; UP000005640; Chromosome 16 Bgee; ENSG00000074071; - CleanEx; HS_MRPS34; - ExpressionAtlas; P82930; baseline and differential Genevisible; P82930; HS GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome GO; GO:0005739; C:mitochondrion; IDA:HPA GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro GO; GO:0032543; P:mitochondrial translation; ISS:UniProtKB GO; GO:0070125; P:mitochondrial translational elongation; TAS:Reactome GO; GO:0070126; P:mitochondrial translational termination; TAS:Reactome InterPro; IPR032053; MRP-S34 Pfam; PF16053; MRP-S34; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Mitochondrion; Polymorphism; Reference proteome; Ribonucleoprotein; Ribosomal protein INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P82929} CHAIN 2 218 28S ribosomal protein S34, mitochondrial /FTId=PRO_0000087730 VARIANT 33 33 L -> I (in dbSNP:rs11552431) /FTId=VAR_052050 SEQUENCE 218 AA; 25650 MW; 58DC48FF63276060 CRC64; MARKKVRPRL IAELARRVRA LREQLNRPRD SQLYAVDYET LTRPFSGRRL PVRAWADVRR ESRLLQLLGR LPLFGLGRLV TRKSWLWQHD EPCYWRLTRV RPDYTAQNLD HGKAWGILTF KGKTESEARE IEHVMYHDWR LVPKHEEEAF TAFTPAPEDS LASVPYPPLL RAMIIAERQK NGDTSTEEPM LNVQRIRMEP WDYPAKQEDK GRAKGTPV
Research Areas
Citations (0)

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Background

Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of asmall 28S subunit and a large 39S subunit. They have an estimated75% protein to rRNA composition compared to prokaryotic ribosomes,where this ratio is reversed. Another difference between mammalianmitoribosomes and prokaryotic ribosomes is that the latter containa 5S rRNA. Among different species, the proteins comprising themitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequencehomology. This gene encodes a 28S subunit protein. Alternate splicevariants of this gene have been described but their full-lengthnature has not been determined.

References

Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Zhang, Z., et al. Genomics 81(5):468-480(2003)Ogawa, F., et al. Biochem. Biophys. Res. Commun. 300(3):789-792(2003)Cavdar Koc, E., et al. J. Biol. Chem. 276(22):19363-19374(2001)O'Brien, T.W., et al. J. Biol. Chem. 275(24):18153-18159(2000)

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$ 80.00
Cat# BP10991a
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