|Other Names||Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3, Development and differentiation-enhancing factor-like 1, Protein up-regulated in liver cancer 1, ASAP3, DDEFL1, UPLC1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes cell proliferation.|
|Tissue Location||Highly expressed in primary hepatocarcinoma. Detected in lung, liver and blood leukocytes|
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This gene encodes a member of a subfamily ofADP-ribosylation factor(Arf) GTPase-activating proteins thatcontain additional ankyrin repeat and pleckstrin homology domains.The Arf GAP domain of this protein catalyzes the hydrolysis of GTPbound to Arf proteins. The encoded protein promotes celldifferentiation and migration and has been implicated in cancercell invasion. Alternative splicing results in multiple transcriptvariants.
Ismail, S.A., et al. Cell 141(5):812-821(2010)Ha, V.L., et al. J. Biol. Chem. 283(22):14915-14926(2008)Fang, Z., et al. Mol. Cell Proteomics 5(8):1437-1449(2006)Okabe, H., et al. Int. J. Oncol. 24(1):43-48(2004)
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