|Other Names||Peroxisome proliferator-activated receptor gamma coactivator-related protein 1, PGC-1-related coactivator, PRC, PPRC1, KIAA0595|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes.|
|Cellular Location||Nucleus. Note=Colocalizes with NRF1.|
|Tissue Location||Strongly expressed in heart and skeletal muscle, moderately in lung, placenta, intestine, liver, kidney, spleen, thymus, colon and brain. Also expressed in several oncocytic thyroid tumors.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is similar to PPAR-gammacoactivator 1 (PPARGC1/PGC-1), a protein that can activatemitochondrial biogenesis in part through a direct interaction withnuclear respiratory factor 1 (NRF1). This protein has been shown tointeract with NRF1. It is thought to be a functional relative ofPPARGC1 that activates mitochondrial biogenesis through NRF1 inresponse to proliferative signals.
Reiling, E., et al. Eur. J. Hum. Genet. 17(8):1056-1062(2009)Vercauteren, K., et al. J. Biol. Chem. 284(4):2307-2319(2009)Raharijaona, M., et al. PLoS ONE 4 (11), E7964 (2009) :Lu, Y., et al. J. Lipid Res. 49(12):2582-2589(2008)Vercauteren, K., et al. J. Biol. Chem. 283(18):12102-12111(2008)
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