|Other Names||NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5, Probable methyltransferase C20orf7, mitochondrial, 211-, NDUFAF5, C20orf7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Arginine hydroxylase involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I, MT-ND1) at early stages (PubMed:18940309, PubMed:27226634). Acts by mediating hydroxylation of 'Arg-111' of NDUFS7 (PubMed:27226634). May also have methyltransferase activity (Probable).|
|Cellular Location||Mitochondrion inner membrane Note=Peripherally localized on the matrix face of the mitochondrial inner membrane.|
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Provided below are standard protocols that you may find useful for product applications.
The NADH-ubiquinone oxidoreductase complex (complex I) ofthe mitochondrial respiratory chain catalyzes the transfer ofelectrons from NADH to ubiquinone, and consists of at least 43subunits. The complex is located in the inner mitochondrialmembrane. This gene encodes a mitochondrial protein that isassociated with the matrix face of the mitochondrial inner membraneand is required for complex I assembly. A mutation in this generesults in mitochondrial complex I deficiency. Multiple transcriptvariants encoding different isoforms have been found for this gene.
Gerards, M., et al. J. Med. Genet. 47(8):507-512(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Sugiana, C., et al. Am. J. Hum. Genet. 83(4):468-478(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
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