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WDR51B Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8TC44 |
|---|---|
| Clone Names | 91218043 |
| Gene ID | 282809 |
|---|---|
| Other Names | POC1 centriolar protein homolog B, Pix1, Proteome of centriole protein 1B, WD repeat-containing protein 51B, POC1B, WDR51B |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | POC1B (HGNC:30836) |
|---|---|
| Synonyms | WDR51B |
| Function | Plays an important role in centriole assembly and/or stability and ciliogenesis (PubMed:20008567, PubMed:32060285). Involved in early steps of centriole duplication, as well as in the later steps of centriole length control (PubMed:19109428). Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation (PubMed:32060285). Required for primary cilia formation, ciliary length and also cell proliferation (PubMed:23015594). Required for retinal integrity (PubMed:25044745). |
| Cellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, spindle pole. Note=Component of both mother and daughter centrioles (PubMed:32060285). Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer. {ECO:0000250|UniProtKB:Q8BHD1, ECO:0000269|PubMed:32060285} |
| Tissue Location | Expressed in the retina. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Required for ciliogenesis.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Pearson, C.G., et al. J. Cell Biol. 187(6):905-920(2009)Keller, L.C., et al. Mol. Biol. Cell 20(4):1150-1166(2009)Hames, R.S., et al. Exp. Cell Res. 314(3):574-589(2008)Lamesch, P., et al. Genomics 89(3):307-315(2007)
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