OTUD3 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q5T2D3 |
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Other Accession | NP_056022.1 |
Clone Names | 91230179 |
Gene ID | 23252 |
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Other Names | OTU domain-containing protein 3, OTUD3, KIAA0459 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | OTUD3 (HGNC:29038) |
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Function | Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (PubMed:23827681, PubMed:32011234, PubMed:35675826). Important regulator of energy metabolism (PubMed:35675826). Glucose and fatty acids trigger its nuclear translocation by CBP-dependent acetylation (PubMed:35675826). In the nucleus, deubiquitinates and stabilizes the nuclear receptor PPARD regulating the expression of various genes involved in glucose and lipid metabolism and oxidative phosphorylation (PubMed:35675826). Also acts as a negative regulator of the ribosome quality control (RQC) by mediating deubiquitination of 40S ribosomal proteins RPS10/eS10 and RPS20/uS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:32011234). |
Cellular Location | Cytoplasm. Nucleus. Note=Glucose or fatty acid promote nuclear translocation upon acetylation. |
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Provided below are standard protocols that you may find useful for product applications.
References
McGovern, D.P., et al. Nat. Genet. 42(4):332-337(2010)Franke, A., et al. Nat. Genet. 42(4):292-294(2010)Barrett, J.C., et al. Nat. Genet. 41(12):1330-1334(2009)Silverberg, M.S., et al. Nat. Genet. 41(2):216-220(2009)Venter, J.C., et al. Science 291(5507):1304-1351(2001)
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