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ICAM2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P13598 |
|---|---|
| Clone Names | 91019057 |
| Gene ID | 3384 |
|---|---|
| Other Names | Intercellular adhesion molecule 2, ICAM-2, CD102, ICAM2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ICAM2 |
|---|---|
| Function | ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. |
| Cellular Location | Membrane; Single-pass type I membrane protein. Cell projection, microvillus {ECO:0000250|UniProtKB:P35330}. Note=Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000250|UniProtKB:P35330} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of theintercellular adhesion molecule (ICAM) family. All ICAM proteinsare type I transmembrane glycoproteins, contain 2-9immunoglobulin-like C2-type domains, and bind to the leukocyteadhesion LFA-1 protein. This protein may play a role in lymphocyterecirculation by blocking LFA-1-dependent cell adhesion. Itmediates adhesive interactions important for antigen-specificimmune response, NK-cell mediated clearance, lymphocyterecirculation, and other cellular interactions important for immuneresponse and surveillance. Several transcript variants encoding thesame protein have been found for this gene.
References
Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Sato, H., et al. Biochim. Biophys. Acta 1790(10):1198-1205(2009)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 18(5):1651-1658(2009)
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