|Other Names||Interleukin-1 receptor type 2, IL-1R-2, IL-1RT-2, IL-1RT2, CD121 antigen-like family member B, CDw121b, IL-1 type II receptor, Interleukin-1 receptor beta, IL-1R-beta, Interleukin-1 receptor type II, CD121b, Interleukin-1 receptor type 2, membrane form, mIL-1R2, mIL-1RII, Interleukin-1 receptor type 2, soluble form, sIL-1R2, sIL-1RII, IL1R2, IL1RB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.|
|Cellular Location||Isoform Short: Secreted|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine receptorthat belongs to the interleukin 1 receptor family. This proteinbinds interleukin alpha (IL1A), interleukin beta (IL1B), andinterleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoyreceptor that inhibits the activity of its ligands. Interleukin 4(IL4) is reported to antagonize the activity of interleukin 1 byinducing the expression and release of this cytokine. This gene andthree other genes form a cytokine receptor gene cluster onchromosome 2q12. Two alternatively spliced transcript variantsencoding the same protein have been reported.
Giroux, S., et al. Bone 47(5):975-981(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Chen, C., et al. Rheumatol. Int. (2010) In press :Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)
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