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HDAC5 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UQL6
Clone Names 4013009
Peptide ID 4013009
Additional Information
Gene ID 10014
Other Names Histone deacetylase 5, HD5, Antigen NY-CO-9, HDAC5, KIAA0600
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1105a was selected from the N-term region of human HDAC5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HDAC5
Synonyms KIAA0600
Function Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1
Tissue Location Ubiquitous.
Research Areas
Citations (0)

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Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with the HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This protein is thought to be associated with colon cancer.


Berger, I., et al., J. Biol. Chem. 278(20):17625-17635 (2003).Zhang, C.L., et al., Mol. Cell. Biol. 22(20):7302-7312 (2002).Lemercier, C., et al., J. Biol. Chem. 277(24):22045-22052 (2002).Huang, Y., et al., Cancer Res. 62(10):2913-2922 (2002).Grozinger, C.M., et al., Proc. Natl. Acad. Sci. U.S.A. 97(14):7835-7840 (2000).

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$ 80.00
Cat# BP1105a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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