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CLEC2A Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6UVW9
Clone Names 100120221
Additional Information
Gene ID 387836
Other Names C-type lectin domain family 2 member A, Keratinocyte-associated C-type lectin, KACL, Proliferation-induced lymphocyte-associated receptor, PILAR, CLEC2A, KACL
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLEC2A
Synonyms KACL
Function Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti-apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.
Cellular Location Cell membrane; Single-pass type II membrane protein
Tissue Location Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.
Research Areas
Citations (0)
citation

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Background

CLEC2A belongs to the CLEC2 family of activation-induced,natural killer gene complex-encoded C-type lectin-like receptors(Spreu et al., 2007 [PubMed 18046548]).

References

Spreu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(11):5100-5105(2010)Ozaki, Y., et al. J. Thromb. Haemost. 7 SUPPL 1, 191-194 (2009) :Huarte, E., et al. Blood 112(4):1259-1268(2008)Spreu, J., et al. Immunogenetics 59(12):903-912(2007)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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$ 277.78
Cat# BP11060c
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