|Other Names||C-type lectin domain family 2 member A, Keratinocyte-associated C-type lectin, KACL, Proliferation-induced lymphocyte-associated receptor, PILAR, CLEC2A, KACL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Mainly expressed in skin. Also expressed in keratinocytes, spleen, thymus, small intestine, peripheral blood monocytes, bone marrow, ovary, testis and skin. High expression in CD8(+), B-lymphocytes and naive CD4(+) T-cells. Restricted mostly to proliferating lymphocytes. Not detected in myeloid leukocytes or natural killer (NK) cells.|
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Provided below are standard protocols that you may find useful for product applications.
CLEC2A belongs to the CLEC2 family of activation-induced,natural killer gene complex-encoded C-type lectin-like receptors(Spreu et al., 2007 [PubMed 18046548]).
Spreu, J., et al. Proc. Natl. Acad. Sci. U.S.A. 107(11):5100-5105(2010)Ozaki, Y., et al. J. Thromb. Haemost. 7 SUPPL 1, 191-194 (2009) :Huarte, E., et al. Blood 112(4):1259-1268(2008)Spreu, J., et al. Immunogenetics 59(12):903-912(2007)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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