|Other Names||Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Small heterodimer partner, NR0B2, SHP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.|
|Cellular Location||Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus|
|Tissue Location||Liver. Low levels of expression were detected in heart and pancreas.|
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The protein encoded by this gene is an unusual orphanreceptor that contains a putative ligand-binding domain but lacks aconventional DNA-binding domain. The gene product is a member ofthe nuclear hormone receptor family, a group of transcriptionfactors regulated by small hydrophobic hormones, a subset of whichdo not have known ligands and are referred to as orphan nuclearreceptors. The protein has been shown to interact with retinoid andthyroid hormone receptors, inhibiting their ligand-dependenttranscriptional activation. In addition, interaction with estrogenreceptors has been demonstrated, leading to inhibition of function.Studies suggest that the protein represses nuclear hormonereceptor-mediated transactivation via two separate steps:competition with coactivators and the direct effects of itstranscriptional repressor function.
Zhou, T., et al. J. Biol. Chem. 285(32):24871-24881(2010)Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Kim, K., et al. Biochem. J. 427(3):413-422(2010)Yang, Z., et al. J. Int. Med. Res. 38(1):142-149(2010)Ondracek, C.R., et al. J. Virol. 83(23):12535-12544(2009)
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