|Other Names||Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Small heterodimer partner, NR0B2, SHP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box- containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.|
|Cellular Location||Nucleus. Cytoplasm. Note=Colocalizes with NEUROD1 in the nucleus|
|Tissue Location||Liver. Low levels of expression were detected in heart and pancreas.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is an unusual orphanreceptor that contains a putative ligand-binding domain but lacks aconventional DNA-binding domain. The gene product is a member ofthe nuclear hormone receptor family, a group of transcriptionfactors regulated by small hydrophobic hormones, a subset of whichdo not have known ligands and are referred to as orphan nuclearreceptors. The protein has been shown to interact with retinoid andthyroid hormone receptors, inhibiting their ligand-dependenttranscriptional activation. In addition, interaction with estrogenreceptors has been demonstrated, leading to inhibition of function.Studies suggest that the protein represses nuclear hormonereceptor-mediated transactivation via two separate steps:competition with coactivators and the direct effects of itstranscriptional repressor function.
Zhou, T., et al. J. Biol. Chem. 285(32):24871-24881(2010)Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Kim, K., et al. Biochem. J. 427(3):413-422(2010)Yang, Z., et al. J. Int. Med. Res. 38(1):142-149(2010)Ondracek, C.R., et al. J. Virol. 83(23):12535-12544(2009)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.