|Other Names||Tumor necrosis factor ligand superfamily member 4, Glycoprotein Gp34, OX40 ligand, OX40L, TAX transcriptionally-activated glycoprotein 1, CD252, TNFSF4, TXGP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a cytokine thatbelongs to the tumor necrosis factor (TNF) ligand family. Thiscytokine is a ligand for receptor TNFRSF4/OX4. It is found to beinvolved in T cell antigen-presenting cell (APC) interactions. Insurface Ig- and CD40-stimulated B cells, this cytokine along withCD70 has been shown to provide CD28-independent costimulatorysignals to T cells. This protein and its receptor are reported todirectly mediate adhesion of activated T cells to vascularendothelial cells.
Karulf, M., et al. J. Immunol. 185(8):4856-4862(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Mosbruger, T.L., et al. J. Infect. Dis. 201(9):1371-1380(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)
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