|Other Names||C-type lectin domain family 11 member A, C-type lectin superfamily member 3, Lymphocyte secreted C-type lectin, Stem cell growth factor, p47, CLEC11A, CLECSF3, LSLCL, SCGF|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CLECSF3, LSLCL, SCGF|
|Function||Stimulates the proliferation and differentiation of hematopoietic precursor cells from various lineages, including erythrocytes, lymphocytes, granulocytes and macrophages. Acts synergistically with other cytokines, including IL-3, GCSF, GMCSF and FLT3 ligand. Suppresses SCF-stimulated erythrocyte proliferation.|
|Cellular Location||Cytoplasm. Secreted|
|Tissue Location||Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.|
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This gene encodes a member of the C-type lectinsuperfamily. The encoded protein is a secreted sulfatedglycoprotein and functions as a growth factor for primitivehematopoietic progenitor cells. An alternative splice variant hasbeen described but its biological nature has not been determined.
Ouma, C., et al. Infect. Immun. 78(1):453-460(2010)Keller, C.C., et al. Infect. Immun. 77(9):3864-3871(2009)Lan, C.C., et al. Br. J. Dermatol. 160(6):1180-1187(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Hollenbeck, S.T., et al. J. Surg. Res. 120(2):288-294(2004)
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