|Other Names||Alpha-aminoadipic semialdehyde synthase, mitochondrial, LKR/SDH, Lysine ketoglutarate reductase, LKR, LOR, Saccharopine dehydrogenase, SDH, AASS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-ketoglutarate reductase and saccharopine dehydrogenase activity, respectively.|
|Tissue Location||Expressed in all 16 tissues examined with highest expression in the liver|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a bifunctional enzyme that catalyzes thefirst two steps in the mammalian lysine degradation pathway. TheN-terminal and the C-terminal portions of this enzyme containlysine-ketoglutarate reductase and saccharopine dehydrogenaseactivity, respectively, resulting in the conversion of lysine toalpha-aminoadipic semialdehyde. Mutations in this gene areassociated with familial hyperlysinemia.
Sacksteder, K.A., et al. Am. J. Hum. Genet. 66(6):1736-1743(2000)Papes, F., et al. Biochem. J. 344 PT 2, 555-563 (1999) :
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