|Other Names||Calcium-binding protein 1, CaBP1, Calbrain, Caldendrin, CABP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Modulates calcium-dependent activity of inositol 1,4,5- triphosphate receptors (ITPRs). Inhibits agonist-induced intracellular calcium signaling. Enhances inactivation and does not support calcium-dependent facilitation of voltage-dependent P/Q-type calcium channels. Causes calcium-dependent facilitation and inhibits inactivation of L-type calcium channels by binding to the same sites as calmodulin in the C-terminal domain of CACNA1C, but resulting in an opposit effects on channel function. Suppresses the calcium-dependent inactivation of CACNA1D (By similarity). Inhibits TRPC5 channels. Prevents NMDA receptor- induced cellular degeneration (By similarity).|
|Cellular Location||Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell membrane; Lipid-anchor; Cytoplasmic side Golgi apparatus. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Note=L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane Isoform S-CaBP1: Cytoplasm, cell cortex. Cell membrane; Lipid-anchor. Note=S-CaBP1 is localized at or near the plasma membrane|
|Tissue Location||Retina and brain. Somatodendritic compartment of neurons. Calbrain was found exclusively in brain where it is abundant in the hippocampus, habenular area in the epithalamus and in the cerebellum|
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The product of this gene belongs to a subfamily of calciumbinding proteins, which share similarity to calmodulin. Calciumbinding proteins are an important component of calcium mediatedcellular signal transduction. Expression of this gene was onlydetected in retina and brain. Study of the mouse homologdemonstrated that groups of cells expressing this protein arelocated in the center or inner border of the inner unclear layer ofretina. Three alternatively spliced variants encoding differentisoforms have been described.
Li, C., et al. J. Biol. Chem. 284(4):2472-2481(2009)Chen, M.L., et al. J. Biomed. Sci. 15(2):169-181(2008)Haynes, L.P., et al. Proteomics 6(6):1822-1832(2006)Wingard, J.N., et al. J. Biol. Chem. 280(45):37461-37470(2005)Zhou, H., et al. J. Biol. Chem. 280(33):29612-29619(2005)
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