|Other Names||Transcription factor BTF3, Nascent polypeptide-associated complex subunit beta, NAC-beta, RNA polymerase B transcription factor 3, BTF3, NACB|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription.|
|Cellular Location||Cytoplasm. Nucleus. Note=The heterodimer with NACA is cytoplasmic|
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This gene encodes the basic transcription factor 3. Thisprotein forms a stable complex with RNA polymerase IIB and isrequired for transcriptional initiation. Alternative splicingresults in multiple transcript variants encoding differentisoforms. This gene has multiple pseudogenes.
Green, C.D., et al. Mol. Cancer Res. 5(11):1191-1200(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Kusumawidjaja, G., et al. Cancer Biol. Ther. 6(3):367-376(2007)Freire, M.A. Gene 345(2):271-277(2005)Harrington, J.J., et al. Nat. Biotechnol. 19(5):440-445(2001)
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