|Other Names||Engulfment and cell motility protein 2, Protein ced-12 homolog A, hCed-12A, ELMO2, CED12A, KIAA1834|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.|
|Cellular Location||Cytoplasm. Cytoplasm, cytosol. Membrane|
|Tissue Location||Widely expressed, with a higher expression in skeletal muscle, kidney and placenta|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene interacts with thededicator of cyto-kinesis 1 protein. Similarity to a C. elegansprotein suggests that this protein may function in phagocytosis ofapoptotic cells and in cell migration. Alternative splicing resultsin multiple transcript variants encoding the same protein.
Bento, J.L., et al. Genomics 92(4):226-234(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)Castelo, R., et al. Nucleic Acids Res. 33(6):1935-1939(2005)
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