Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
ELMO2 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96JJ3 |
|---|---|
| Clone Names | 81006115 |
| Gene ID | 63916 |
|---|---|
| Other Names | Engulfment and cell motility protein 2, Protein ced-12 homolog A, hCed-12A, ELMO2, CED12A, KIAA1834 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ELMO2 |
|---|---|
| Synonyms | CED12A, KIAA1834 |
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Cellular Location | Cytoplasm. Cytoplasm, cytosol. Membrane |
| Tissue Location | Widely expressed, with a higher expression in skeletal muscle, kidney and placenta. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene interacts with thededicator of cyto-kinesis 1 protein. Similarity to a C. elegansprotein suggests that this protein may function in phagocytosis ofapoptotic cells and in cell migration. Alternative splicing resultsin multiple transcript variants encoding the same protein.
References
Bento, J.L., et al. Genomics 92(4):226-234(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)Zhang, Y., et al. Mol. Cell Proteomics 4(9):1240-1250(2005)Castelo, R., et al. Nucleic Acids Res. 33(6):1935-1939(2005)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
