|Other Names||FYVE, RhoGEF and PH domain-containing protein 6, Zinc finger FYVE domain-containing protein 24, FGD6, KIAA1362, ZFYVE24|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton|
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Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)Jin, J., et al. Curr. Biol. 14(16):1436-1450(2004)
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