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HPR Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P00739
Clone Names 80902111
Additional Information
Gene ID 3250
Other Names Haptoglobin-related protein, HPR
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HPR
Function Primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL). This HDL particle, termed trypanosome lytic factor-1 (TLF-1), mediates human innate immune protection against many species of African trypanosomes. Binds hemoglobin with high affinity and may contribute to the clearance of cell-free hemoglobin to allow hepatic recycling of heme iron.
Cellular Location Secreted. Note=Secreted into blood plasma and associated with subtypes of high density lipoproteins (HDL).
Tissue Location In adult liver the amount of HPR mRNA is at the lower limit of detection, therefore the extent of its expression is at most less than 1000-fold that of the HP1F gene. No HPR mRNA can be detected in fetal liver. Expressed in Hep-G2 and leukemia MOLT-4 cell lines.
Research Areas
Citations (0)
citation

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Background

Ubiquitous transcription factor required for a diverse set of processes. It is a component of the CCR4 complex involved in the control of gene expression (By similarity).

References

Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Harrington, J.M., et al. J. Biol. Chem. 284(20):13505-13512(2009)Widener, J., et al. PLoS Pathog. 3(9):1250-1261(2007)Vanhollebeke, B., et al. Proc. Natl. Acad. Sci. U.S.A. 104(10):4118-4123(2007)

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$ 277.78
Cat# BP11111c
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Availability: 2 weeks
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