GGCX Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P38435 |
---|---|
Clone Names | 80513164 |
Gene ID | 2677 |
---|---|
Other Names | Vitamin K-dependent gamma-carboxylase, Gamma-glutamyl carboxylase, Peptidyl-glutamate 4-carboxylase, Vitamin K gamma glutamyl carboxylase, GGCX, GC |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GGCX |
---|---|
Synonyms | GC |
Function | Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide (PubMed:17073445). Catalyzes gamma-carboxylation of various proteins, such as blood coagulation factors (F2, F7, F9 and F10), osteocalcin (BGLAP) or matrix Gla protein (MGP) (PubMed:17073445). |
Cellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme which catalyzes theposttranslational modification of vitamin K-dependent protein. Manyof these vitamin K-dependent proteins are involved in coagulationso the function of the encoded enzyme is essential for hemostasis.Mutations in this gene are associated with vitamin K-dependentcoagulation defect and PXE-like disorder with multiple coagulationfactor deficiency. Multiple transcript variants encoding differentisoforms have been found for this gene.
References
Higgins-Gruber, S.L., et al. J. Biol. Chem. 285(41):31502-31508(2010)King, C.R., et al. Thromb. Haemost. 104(4):750-754(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Ikejiri, M., et al. Int. J. Hematol. 92(2):302-305(2010)Schelleman, H., et al. Br J Clin Pharmacol 70(3):393-399(2010)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.