|Other Names||Alpha-(1, 6)-fucosyltransferase, Alpha1-6FucT, Fucosyltransferase 8, GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1, 6-fucosyltransferase, GDP-fucose--glycoprotein fucosyltransferase, Glycoprotein 6-alpha-L-fucosyltransferase, FUT8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein Note=Membrane-bound form in trans cisternae of Golgi|
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Provided below are standard protocols that you may find useful for product applications.
This enzyme belongs to the family of fucosyltransferases.The product of this gene catalyzes the transfer of fucose fromGDP-fucose to N-linked type complex glycopeptides. This enzyme isdistinct from other fucosyltransferases which catalyze alpha1-2,alpha1-3, and alpha1-4 fucose addition. The expression of this genemay contribute to the malignancy of cancer cells and to theirinvasive and metastatic capabilities. Alternatively splicedvariants encoding different isoforms have been identified.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Wang, X., et al. J. Biochem. 145(5):643-651(2009)Kudo, T., et al. Mol. Cancer 6, 32 (2007) :Ihara, H., et al. Glycobiology 16(4):333-342(2006)Ito, Y., et al. Cancer Lett. 200(2):167-172(2003)
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