|Other Names||5-hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, Serotonin receptor 2B, HTR2B|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome|
|Tissue Location||Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.|
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Multiple receptor subtypes of serotonin neurotransmitterswith multiple physiologic functions have been recognized. The5-HT-2 receptors mediate many of the central and peripheralphysiologic functions of serotonin. Cardiovascular effects includecontraction of blood vessels and shape changes in platelets;central nervous system effects include neuronal sensitization totactile stimuli and mediation of hallucinogenic effects ofphenylisopropylamine hallucinogens.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Svejda, B., et al. Cancer 116(12):2902-2912(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
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