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HTR2B Antibody (C-term E423) Blocking peptide

Synthetic peptide

Product Information
Primary Accession P41595
Clone Names 81110090
Peptide ID 81110090
Additional Information
Gene ID 3357
Other Names 5-hydroxytryptamine receptor 2B, 5-HT-2B, 5-HT2B, Serotonin receptor 2B, HTR2B
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name HTR2B
Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down- stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5- hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
Cellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, synaptosome
Tissue Location Ubiquitous. Detected in liver, kidney, heart, pulmonary artery, and intestine. Detected at lower levels in blood, placenta and brain, especially in cerebellum, occipital cortex and frontal cortex.
Research Areas
Citations (0)

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Multiple receptor subtypes of serotonin neurotransmitterswith multiple physiologic functions have been recognized. The5-HT-2 receptors mediate many of the central and peripheralphysiologic functions of serotonin. Cardiovascular effects includecontraction of blood vessels and shape changes in platelets;central nervous system effects include neuronal sensitization totactile stimuli and mediation of hallucinogenic effects ofphenylisopropylamine hallucinogens.


Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010)Svejda, B., et al. Cancer 116(12):2902-2912(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :

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$ 80.00
Cat# BP11124a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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