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INHBA Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P08476
Clone Names 81201092
Additional Information
Gene ID 3624
Other Names Inhibin beta A chain, Activin beta-A chain, Erythroid differentiation protein, EDF, INHBA
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name INHBA
Function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Cellular Location Secreted.
Research Areas
Citations (0)
citation

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Background

The inhibin beta A subunit joins the alpha subunit to forma pituitary FSH secretion inhibitor. Inhibin has been shown toregulate gonadal stromal cell proliferation negatively and to havetumor-suppressor activity. In addition, serum levels of inhibinhave been shown to reflect the size of granulosa-cell tumors andcan therefore be used as a marker for primary as well as recurrentdisease. Because expression in gonadal and various extragonadaltissues may vary severalfold in a tissue-specific fashion, it isproposed that inhibin may be both a growth/differentiation factorand a hormone. Furthermore, the beta A subunit forms a homodimer,activin A, and also joins with a beta B subunit to form aheterodimer, activin AB, both of which stimulate FSH secretion.Finally, it has been shown that the beta A subunit mRNA isidentical to the erythroid differentiation factor subunit mRNA andthat only one gene for this mRNA exists in the human genome.

References

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)Shi, F.T., et al. J. Clin. Endocrinol. Metab. 95 (10), E172-E180 (2010) :Lascorz, J., et al. Carcinogenesis 31(9):1612-1619(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :

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$ 277.78
Cat# BP11126a
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