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IRGM Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession A1A4Y4
Clone Names 90121011
Peptide ID 90121011
Additional Information
Gene ID 345611
Other Names Immunity-related GTPase family M protein, 365-, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 2647 macrophage protein 47 homolog, LRG-47, IRGM, IFI1, IRGM1, LRG47
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms IFI1, IRGM1, LRG47
Function Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).
Cellular Location Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, phagocytic cup Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi.
Tissue Location Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.
Research Areas
Citations (0)

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This gene encodes a member of the p47 immunity-relatedGTPase family. The encoded protein may play a role in the innateimmune response by regulating autophagy formation in response tointracellular pathogens. Polymorphisms that affect the normalexpression of this gene are associated with a susceptibility toCrohn's disease and tuberculosis.


Che, N., et al. Clin. Chim. Acta 411 (21-22), 1645-1649 (2010) :Wolfkamp, S.C., et al. Eur J Gastroenterol Hepatol 22(8):933-937(2010)Latiano, A., et al. Inflamm. Bowel Dis. 16(7):1108-1117(2010)Prescott, N.J., et al. Hum. Mol. Genet. 19(9):1828-1839(2010)Bekpen, C., et al. PLoS Genet. 5 (3), E1000403 (2009) :

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$ 80.00
Cat# BP11128b
Availability: In Stock
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