|Other Names||Immunity-related GTPase family M protein, 365-, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LPS-stimulated RAW 2647 macrophage protein 47 homolog, LRG-47, IRGM, IFI1, IRGM1, LRG47|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||IFI1, IRGM1, LRG47|
|Function||Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity).|
|Cellular Location||Golgi apparatus membrane. Cell membrane. Cytoplasmic vesicle, phagosome membrane. Cytoplasmic vesicle, autophagosome membrane. Cell projection, phagocytic cup Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi.|
|Tissue Location||Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes.|
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This gene encodes a member of the p47 immunity-relatedGTPase family. The encoded protein may play a role in the innateimmune response by regulating autophagy formation in response tointracellular pathogens. Polymorphisms that affect the normalexpression of this gene are associated with a susceptibility toCrohn's disease and tuberculosis.
Che, N., et al. Clin. Chim. Acta 411 (21-22), 1645-1649 (2010) :Wolfkamp, S.C., et al. Eur J Gastroenterol Hepatol 22(8):933-937(2010)Latiano, A., et al. Inflamm. Bowel Dis. 16(7):1108-1117(2010)Prescott, N.J., et al. Hum. Mol. Genet. 19(9):1828-1839(2010)Bekpen, C., et al. PLoS Genet. 5 (3), E1000403 (2009) :
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